Glutathione Transferase of Schistoma Mansoni and its Interaction with Praziquantel.

Hasler, Julia. A. (2013) Glutathione Transferase of Schistoma Mansoni and its Interaction with Praziquantel. UNSPECIFIED.

Full text not available from this repository.
Official URL: http://ir.nust.ac.zw/xmlui/handle/123456789/246

Abstract

Presented at the Research Day Seminar 1990, University of Zimbabwe,Glutathione S-transferases play an important role in the excretion of xenobiotics as well as in the antioxidant defence system of cells. The glutathione S-transferase of the parasitic' trematode Schistosoma mansoni has been studied. The results of preliminary experiments are presented here. The pH optimum of the enzyme was found to be 9.5 which is much higher than that of the mammalian liver enzyme. The apparent Km for the substrate 1 chloro 2,4 dinitrobenzene (CDNBL was 1.25 mN and for glutathione was 0.37 roM. The antischistosomal drug Praziquantel was found to inhibit the conjugation of CDNB in a competitive manner. The implications of these results will be discussed.

Item Type: Other
Uncontrolled Keywords: Glutathione,Transferase,Schistoma Mansoni,Praziquantel
Divisions: Universities > State Universities > National University of Science and Technology
Depositing User: Mr. Edmore Sibanda
Date Deposited: 30 Nov 2015 22:30
Last Modified: 30 Nov 2015 22:30
URI: http://researchdatabase.ac.zw/id/eprint/1093

Actions (login required)

View Item View Item