Xenobiotic metabolizing enzymes of the freshwater snails.Planorbella and lymnaea (RADIX)Natalensis.

Naik, Y.S (1994) Xenobiotic metabolizing enzymes of the freshwater snails.Planorbella and lymnaea (RADIX)Natalensis.

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Official URL: http://ir.nust.ac.zw/xmlui/handle/123456789/472

Abstract

Journal of medical and applie macology,Very little is known about the ability of snails to metabolise and remove xenobiotics such as molluscicides. The present study was conducted to determine whether the freshwater snails Planorbella duryi and Lymnaea (Radix) nntaIensis possess two of the major enzyme systems of detoxication, namely the P450 monooxygenase system and the glutathione Stransferases. We were able to measure microsomal cytochrome b5 and NADPH cytochrome c reductase activity, indicating a functional mixed function oxidase system. However, probing with three known substrates for the mammalian enzyme, we were unable to detect any cytochrome P450 mediated activity. Glutathione Stransferase activity was detectable in cytosolic fractions. In general, the activities detectable in snails were much lower than in mammalian liver preparations. The existence of these enzymes in snails suggests that studies should be undertaken to observe the interaction between these enzymes and xenobiotics such as candidate molluscicides. Key words: Planorbella duyi, Lyrnnaea (Radix) natalensis, cytochrome P450, glutathione,lnternational Program in Chemical Science, Uppsala University Sweden and Research Board, University of Zimbabwe.

Item Type: Article
Uncontrolled Keywords: Planorbella duyi,Lyrnnaea (Radix) natalensis,cytochrome P450,Glutathione S-transferase
Divisions: Universities > State Universities > National University of Science and Technology
Depositing User: Mr. Edmore Sibanda
Date Deposited: 01 Dec 2015 01:02
Last Modified: 01 Dec 2015 01:02
URI: http://researchdatabase.ac.zw/id/eprint/1240

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