Effects of phenobarbital and 3-methylcholanthrene pretreatment on the pharmacokinetics of praziquantel in rats.

Masimirembwa, C.M (1992) Effects of phenobarbital and 3-methylcholanthrene pretreatment on the pharmacokinetics of praziquantel in rats.

Full text not available from this repository.
Official URL: http://ir.nust.ac.zw/xmlui/handle/123456789/391

Abstract

An article with illustrations.,The effects of phenobarbital (PB) and 3-methylcholanthrene (MC) pretreatment on the phannac~kinetics of praziquantel (PZQ), a schistosomicide were studied in Spnrgue-Dawley rats. Blood samples at different time intervals were obtained by severing the tail vein and were analyzed for unchanged PZQ by HPLC. The PB-pretreated rats showed a &fold decrtase in AUC, a 5-fold decrease in Cmax and an 8-fold increase in Ch compared to the saline treated controls. The MC-pretreated rats and their oliveoil treated controls did not show any statistically significant diffmnces in the above parameters. These results suggest that PZQ is extensively metabolised by PB-inducible cytochrome P-450 isoforms and not by MC-inducible isoforms. These findings also suggest that the bioavailability of praziquantel could be altered to a significant extent in humans taking drugs that are phenobarbital type inducers.,Research Board of the University of Zimbabwe and the International Programme in the Chemical Sciences, Sweden.

Item Type: Article
Uncontrolled Keywords: Praziquante,pharmacokinetics,phenobarbital,3-methylcholanthrene,cytochrome P450 induction
Divisions: Universities > State Universities > National University of Science and Technology
Depositing User: Mr. Edmore Sibanda
Date Deposited: 01 Dec 2015 01:02
Last Modified: 01 Dec 2015 01:02
URI: http://researchdatabase.ac.zw/id/eprint/1245

Actions (login required)

View Item View Item