The effect of schistosomiasis on the covalent binding of 2-acetylaminofluorene to mouse liver macromolecules in vivo and in vitro

Siwela, Andrew H. (1990) The effect of schistosomiasis on the covalent binding of 2-acetylaminofluorene to mouse liver macromolecules in vivo and in vitro.

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Official URL: http://ir.nust.ac.zw/xmlui/handle/123456789/535

Abstract

1. Sprague DH, Yang JC and Ngai SH, Effects of isoflurane and halothane on contractility and the cyclic 3', 5'-adenosine monophosphate system in the rat aorta. Anesthesiology 40: 162-170, 1974. 2. Aronstam RS, Anthony BL and Dennison RL Jr, Halothane effects on muscarinic acetylcholine receptor binding in rat brain. Biochem Pharmaco135: 667-672, 1986.,The covalent binding of [14C]acetylaminofluorene (AAF) to macromolecules in vivo and in vitro was measured in Schistosoma mansoni-infected and in non-infected mice. Liver microsomes from infected mice demonstrated a 42% decreased capacity to mediate covalent binding of AAF to DNA. In addition, the extent of binding of AAF to liver macromolecules in vivo was generally less in infected than non-infected mice.,Research Support, Non-U.S. Gov't, In Vitro

Item Type: Article
Uncontrolled Keywords: schistosomiasis,covalent binding,acetylaminofluorene,mouse liver,macromolecules,vivo,vitro,Gene Ontology,Species,Chemicals
Divisions: Universities > State Universities > National University of Science and Technology
Depositing User: Mr. Edmore Sibanda
Date Deposited: 01 Dec 2015 01:32
Last Modified: 01 Dec 2015 01:32
URI: http://researchdatabase.ac.zw/id/eprint/1276

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