Assessing the Impact of Drug Resistance on the Transmission Dynamics of Typhoid Fever

Mushayabasa, S. (2013) Assessing the Impact of Drug Resistance on the Transmission Dynamics of Typhoid Fever.

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Official URL: http://ir.nust.ac.zw/xmlui/handle/123456789/403

Abstract

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.,Typhoid fever continues to be a major public health problem in the developing world. Antibiotic therapy has been the main stay of treating typhoid fever for decades.The emergence of drug-resistant typhoid strain in the last two decades has been a major problem in tackling this scourge. A mathematical model for investigating the impact of drug resistance on the transmission dynamics of typhoid fever is developed. The reproductive number for the model has been computed. Numerical results in this study suggest that when a typhoid outbreak occurs with more drug-sensitive cases than drug-resistant cases, then it may take 10?15 months for symptomatic drug-resistant cases to outnumber all typhoid cases, and it may take an average of 15?20 months for nonsymptomatic drug-resistant cases to outnumber all drug-sensitive cases.

Item Type: Article
Uncontrolled Keywords: Typhoid fever,Drug Resistance,Transmission Dynamics
Divisions: Universities > State Universities > National University of Science and Technology
Depositing User: Mr. Edmore Sibanda
Date Deposited: 01 Dec 2015 02:02
Last Modified: 01 Dec 2015 02:02
URI: http://researchdatabase.ac.zw/id/eprint/1304

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