Alteration of paracetamol pharmacokinetics in BALB/C mice infected with Schistosoma mansoni

Mukanganyama, S. (1997) Alteration of paracetamol pharmacokinetics in BALB/C mice infected with Schistosoma mansoni.

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Objective: To determine whether the BALBIC mouse is a suitable model for the study of drug pharmacokinetics in S.rnansoni infection. Design: Male and female BALBIC mice were exposed to cercariae of Smansoni. At the acute (eight weeks post infection) and chronic (14 weeks post infection) stages of infection the animals were treated (i.p.) with a single injection of paracetamol. The pharmacokinetics of paracetamol were then determined for each group and compared to their respective controls. Subjects/Mode1: B ALBIC mice. Setting: Laboratory study. Main Outcome Measures: The altered pharamacokinetics observed in Smansoni infected mice are similar to those observed for humans. Results: Our data indicate that in both sexes of mice at both stages of infection with S.mansoni the Cmar was not dramatically reduced while the Tmax was delayed. The alterations are more pronounced at the chronic stage of infection. These results are similar to those obtained by other workers studying humans. Conclusion: The BALBIC mouse is likely to be a suitable model for the study of pharmacokinetics of selected drugs in schistosome infection.,Research Board, University of Zimbabwe and the International Programme in Chemical Sciences, Uppsala Univerity, Sweden.

Item Type: Article
Uncontrolled Keywords: Schistosoma mansoni,paracetamol,pharmacokinetics
Divisions: Universities > State Universities > National University of Science and Technology
Depositing User: Mr. Edmore Sibanda
Date Deposited: 01 Dec 2015 02:32
Last Modified: 01 Dec 2015 02:32

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