Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium.

Nausch, Norman and Bourke, Claire D and Appleby, Laura J and Rujeni, Nadine and Lantz, Olivier and Trottein, François and Midzi, Nicholas and Mduluza, Takafira and Mutapi, Francisca (2012) Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium. p. 472. ISSN 2045-2322

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Abstract

Characterisation of protective helminth acquired immunity in humans or experimental models has focused on effector responses with little work conducted on memory responses. Here we show for the first time, that human helminth infection is associated with altered proportions of the CD4+ memory T cells, with an associated alteration of T(H)1 responses. The reduced CD4+ memory T cell proportions are associated with a significantly lower ratio of schistosome-specific IgE/IgG4 (marker for resistance to infection/re-infection) in uninfected older people. Helminth infection does not affect the CD8+ memory T cell pool. Furthermore, we show for the first time in a helminth infection that the CD4+ memory T cell proportions decline following curative anti-helminthic treatment despite increased CD4+ memory cell replication. Reduced accumulation of the CD4+ memory T cells in schistosome-infected people has implications for the development of natural or vaccine induced schistosome-specific protective immunity as well as for unrelated pathogens.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
Depositing User: Professor Takafira MDULUZA
Date Deposited: 26 Nov 2012 06:37
Last Modified: 26 Nov 2012 06:37
URI: http://researchdatabase.ac.zw/id/eprint/202

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