Determination of appropriate clomipramine dosage among depressed African outpatients in Dar es Salaam, Tanzania

Kilonzo, G.P. (1994) Determination of appropriate clomipramine dosage among depressed African outpatients in Dar es Salaam, Tanzania.

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Official URL: http://hdl.handle.net/10646/2508

Abstract

In an open clomipramine dose finding study, 33 depressed indigenous African outpatients were randomly assigned to two regimens of treatment with 125 mg and 75 mg oral medications daily. At the end of eight weeks of treatment, 16 patients (48,5 pc) were on the 75 mg regime, and 17 (54,8 pc) were on 125 mg. Analysis of depression scores cm the Beck-Rafaelsen scale indicated improvements of depression in both regimes of equal magnitude. Analysis of variance showed no statistically significant difference on dose response between the two regimes. The higher doses, however, were associated with more drowsiness and tremulousness. It is suggested that Black African patients respond to tricyclic antidepressants in much lower doses than those recommended in Western textbooks. It is also apparent that side effects of tricyclic antidepressants, which have been implicated in non-compliance to medication, could be avoided without compromising treatment outcome.

Item Type: Article
Uncontrolled Keywords: Health
Divisions: Universities > State Universities > University of Zimbabwe
Depositing User: Mr. Edmore Sibanda
Date Deposited: 03 Jan 2016 01:31
Last Modified: 03 Jan 2016 01:31
URI: http://researchdatabase.ac.zw/id/eprint/2754

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