Occurrence of diabetogenic changes in pregnancy among black women in an urban setting

Makuyana, D. (2005) Occurrence of diabetogenic changes in pregnancy among black women in an urban setting.

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Official URL: http://hdl.handle.net/10646/2825


Objective: To find out if pregnancy in black Zimbabwean women is a diabetogenic state using basal blood levels of cortisol, insulin, C-peptide and glucose. Methods: 111 women (28 non-pregnant, 29 first trimester, 26 second trimester and 28 third trimester) aged between 18 and 35 years were recruited for the study. Fasting plasma cortisol, insulin, C-peptide and glucose were determined by standard methods. The glucose/insulin ratio was used as an index of insulin sensitivity and the C-peptide/glucose ratio as well as the homeostasis assessment model (HOMA) as an index of insulin resistance. Results: The means of fasting plasma cortisol levels were significantly elevated, p <0.0001 among the four groups (non-pregnant, first, second and third trimester women). Fasting plasma insulin levels peaked during the third trimester and significant differences were noted among all women, p <0.05. Similar data was obtained for C-peptide levels (a better indicator of beta-cell insulin secretory activity) among the groups, p <0.01. The means of fasting plasma glucose levels were significantly decreased with advancing gestation, p <0.0001. Significantly lower glucose/insulin ratios, a measure of insulin sensitivity and elevated C-peptide/glucose ratios, an index of insulin resistance, were demonstrated among the women, (p <0.05 and <0.01 respectively). Conclusion: The basal data presented in this paper clearly demonstrates that the diabetogenic effects of pregnancy are also expressed by Zimbabwean black women, especially in late gestation

Item Type: Article
Uncontrolled Keywords: pregnancy,gestational diabetes,black Zimbabwean women
Divisions: Universities > State Universities > University of Zimbabwe
Depositing User: Mr. Edmore Sibanda
Date Deposited: 08 Oct 2016 23:31
Last Modified: 08 Oct 2016 23:31
URI: http://researchdatabase.ac.zw/id/eprint/3899

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