Enantioselective analysis of chiral pharmaceuticals in wastewater and environmental water samples

Sanganyado, Edmond and Gan, Jay (2013) Enantioselective analysis of chiral pharmaceuticals in wastewater and environmental water samples. In: SETAC North America 34th Annual Meeting, November 17-22, 2013, Nashville, Tennessee.

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Abstract

Chiral human pharmaceuticals including atenolol, fluoxetine, ibuprofen and tramadol are environmental pollutants of emerging concern. Normal-phase and reversed-phase chiral liquid chromatography (HPLC-UV) methods were developed to resolve stereoisomers of atenolol, fluoxetine, ibuprofen and tramadol. In normal phase, enantiomeric resolution (RS) of tramadol was 7.95 and ibuprofen was 1.66, obtained using Chiralpak AD-H and Chiralcel OJ columns, respectively. The mobile phases were n-hexane/2-propanol/diethylamine (90:10:0.1, v/v/v) and n-hexane/2-propanol/trifluoroacetic acid (98:2:0.1, v/v/v) for the enantioseparation of tramadol and ibuprofen, respectively. Enantiomers of atenolol and fluoxetine were resolved using Chirobiotic V column and a mobile phase constituting methanol, 15 mM ammonium acetate and 0.005% formic acid. The Rs of atenolol and fluoxetine were 2.40 and 2.24, respectively. The methods were subsequently used to evaluate changes in enantiomeric composition of these compounds in river water and wastewater, as well as sediments.

Item Type: Conference or Workshop Item (Speech)
Subjects: Q Science > QD Chemistry
Depositing User: Mr Edmond Sanganyado
Date Deposited: 30 Nov 2015 15:02
Last Modified: 30 Nov 2015 15:02
URI: http://researchdatabase.ac.zw/id/eprint/355

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